کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538933 | 1122159 | 2011 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts](/preview/png/2538933.png)
The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar irradiation-induced oxidative injury. The photoprotection was paralleled by decreases in the elastases-type protease activity and matrix-metalloproteinases-1 expression in solar-irradiated fibroblasts. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production. The results suggest that by virtue of its pro-oxidant action and the subsequent glutathione antioxidant response, Sch B or Sch C may offer the prospect of preventing skin photo-aging.
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Journal: Fitoterapia - Volume 82, Issue 4, June 2011, Pages 682–691