کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538978 1122160 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.
چکیده انگلیسی

Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5′-methoxy-6-methyl-biphenyl-3,4,3′-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoaltenuene (6), altenuene (7), dihydroaltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1–13 were screened for their antimicrobial and radical scavenging activities. Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC50 of 97.93 ± 1.12 μM. Compounds 11–13 showed strong activity against Bacillus subtilis with IC50 in the range of 1–5 μM. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC50 of 20.95 ± 1.56 μM. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4–8 were discussed.

Two new polyketides (1–2) along with eleven known compounds (3–13) were isolated from the culture of the endolichenic fungus UlocladiumXylaria sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. All the compounds were evaluated for their antimicrobial and radical scavenging activities.Figure optionsDownload high-quality image (69 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 83, Issue 1, January 2012, Pages 209–214
نویسندگان
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