کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2538999 | 1122161 | 2011 | 6 صفحه PDF | دانلود رایگان |

This work studied a relationship between HO-1/CO system and lipid peroxidation with consequent effects on liver functions and NOS-2. We focused on curcumin pretreatment in rat toxic model of d-galactosamine and lipopolysaccharide. Hepatocyte viability, lipid peroxidation, antioxidant status, ALT and AST were evaluated. HO-1 and NOS-2 expressions and respective enzyme activity were determined. Curcumin caused decreases in ALT and AST levels as well as in lipid peroxidation. Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p = 0.001), but reduced NOS-2 (4.1-fold, p = 0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model.
Curcumin formula in bis-keto-form — polyphenolic, conjugated structure having hepatoprotective effect that is associated with induction of heme oxygenase (HO-1) and inhibition of inducible nitric oxide synthase (NOS-2).Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 5, July 2011, Pages 786–791