Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves on CCl4-induced hepatotoxicity in rats

The hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves were evaluated against carbon tetrachloride induced hepatic damage in Sprague–Dawley rats. The elevated levels of serum ALT, AST, ALP, ALB, TP, HA, LN, TG, and CHO were restored towards normalization significantly by GBP in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections. Meanwhile, GBP also produced a significant and dose-dependent reversal of CCl4-diminished activity of the antioxidant enzymes and reduced CCl4-elevated level of MDA. In general, the effects of GBP were not significantly different from those of the standard drug Essentiale.

Hepatoprotective effects of polyprenols from Ginkgo biloba L. leaves (GBP) on CCl4-induced hepatotoxicity in Sprague–Dawley rats were investigated in this paper. The effects of GBP were comparable and not significantly different from those of the standard drug Essentiale. The results indicate that GBP could be explored as a potentially promising additive for liver diseases.Figure optionsDownload as PowerPoint slide