کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539171 | 1122167 | 2010 | 6 صفحه PDF | دانلود رایگان |
We studied effects of hydrolysable tannins on rat papillary muscle contractions induced by propranolol. The developed force of papillary muscle was measured isometrically with an inductive force transducer. The IC50 values for digallic acid, gallic acid, germin D, praecoxin A and 1-desgalloyl rugosin F were 4.2 × 10− 5 M, 1.3 × 10− 4 M, 1,4 × 10− 4 M, 1.5 × 10− 4 and 1.7 × 10− 4 M, respectively. Incubation with tannins significantly attenuated the propranolol-induced negative inotropic contractile response. These results show that hydrolysable tannins depress muscle contractions and potentiate the activities of β-adrenergic blocker.
Digallic acid(DA) depress cardiac muscle contraction and propranolol(PP)-induced negative inotropism.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 81, Issue 7, October 2010, Pages 820–825