Three new phenolic glycosides from Curculigo orchioides G.

Three new phenolic glycosides, curculigosides F–H (1–3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F–H (1–3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC50 value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line.

Fig. 1. The structures of compounds 1–3.Figure optionsDownload as PowerPoint slide