کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539211 | 1122169 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity Phenolic glycosides from Dodecadenia grandiflora and their glucose-6-phosphatase inhibitory activity](/preview/png/2539211.png)
Phytochemical investigation of Dodecadenia grandiflora leaves led to the isolation and identification of three phenolic glycosides, designated 1-[(4′-O-(E)-p-coumaroyl)-β-d-glucopyranosyl]-oxy-2-phenol (1), 1-[(6′-O-(E)-p-coumaroyl)-β-d-glucopyranosyl]-oxy-2-phenol (2) and 1-[O-β-d-glucopyranosyl(1→2)-β-d-glucopyranosyl]-oxy-2-phenol (3), along with nine known compounds. Compounds 1, 2, 5 and 9 exhibited significant glucose-6-phosphatase inhibitory activity (63.7, 66.9, 82.9 and 85.4%) with IC50 values of 88.5, 81.0, 51 and 50 μM respectively. On the basis of biological results, a structure–activity relationship has been discussed.
Three new compounds were isolated from D. grandiflora leaves, these compounds exhibited significant glucose-6-phosphatase inhibitory activity.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 81, Issue 6, September 2010, Pages 475–479