New cardenolides from the stem bark of Trewia nudiflora

Phytochemical investigation of the stem bark of Trewia nudiflora led to the isolation of two new cardenolides, trewianin (1) and trewioside (2), along with scopoletin (3) and indole-3-carboxylic acid (4). Structures were established by 1D- and 2D NMR spectroscopy, HR-MS analysis, and by comparison with literature data.

Graphical AbstractPhytochemical investigation of the stem bark of Trewia nudiflora led to the isolation of two new cardenolides, trewianin (1) and trewioside (2), along with scopoletin and indole-3-carboxylic acid.Figure optionsDownload as PowerPoint slide