کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539229 1122169 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Puerarin exhibits weak estrogenic activity in female rats
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Puerarin exhibits weak estrogenic activity in female rats
چکیده انگلیسی

A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co), but it increased the number of uterine glands. In long-term treatment, mature rats were injected with 7.0 mg/kg BW/day of puerarin for 140 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the number of uterine glands, but a significant increase in the %Co was observed from day 98 onwards.

Subcutaneous injection of puerarin for 140 days in mature female rats exhibited a significant increase in the percent of cornified cells from day 98 onwards, compared to the DW group.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 81, Issue 6, September 2010, Pages 569–576
نویسندگان
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