Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells

A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3β, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5), canophyllic acid (6), 3-oxo-friedelan-28-oic acid (7), and oleanolic acid (8) by spectroscopic methods (NMR, EI-MS). The growth inhibitory effects of these triterpenoids on human leukemia HL-60 cells were determined.

A new friedelane-type triterpene, 3β, 23-epoxy-friedelan-28-oic acid (1) along with seven known triterpenes, was isolated from Calophyllum inophyllum. The cell inhibitory effects against HL-60 cells were determined.Figure optionsDownload as PowerPoint slide