کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539265 | 1122170 | 2010 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Antioxidant and enzyme inhibition activities and chemical profiles of Polygonum sachalinensis F.Schmidt ex Maxim (Polygonaceae) Antioxidant and enzyme inhibition activities and chemical profiles of Polygonum sachalinensis F.Schmidt ex Maxim (Polygonaceae)](/preview/png/2539265.png)
Polygonum sachalinensis is a widespread invasive plant in Europe. Chemical profiles of its different organs were studied by HPLC-UV-ESI/MS. Seven major constituents quercetin-3-O-β-D-galactopyranoside, quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C, hydropiperoside, and vanicoside B were isolated and identified. The free radical-scavenging, α/β-glucosidase, and acetylcholinesterase inhibitory activities of crude MeOH extracts and isolated compounds were studied. The structure–activity relationships were discussed. The chemical profiles revealed flavonoids and phenylpropanoids are the major compounds of all the organs of this plant. Quercetin-3-O-arabinopyranoside, lapathoside D, N-trans-feruloyltyramine, lapathoside C and hydropiperoside were isolated from this species for the first time. In the α-glucosidase bioassay, quercetin-3-O-β-D-galactopyranoside, lapathoside D and N-trans-feruloyltyramine demonstrated stronger activities than the positive reference acarbose. The trend in scavenging power showed no relation to enzyme inhibition in the test models.
Bioactivity screening showed free radical-scavenging, α/β-glucosidase, and acetylcholinesterase inhibitory activities of MeOH extracts of Polygonum sachalinensis. HPLC-UV-ESI/MS analysis demonstrated the chemical profiles of MeOH extracts. The activities of seven major compounds isolated were studied, among which compounds 2–6 were first reported from this species.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 81, Issue 2, March 2010, Pages 124–131