کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539267 1122170 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The phenylpropanoids of Aster flaccidus
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The phenylpropanoids of Aster flaccidus
چکیده انگلیسی

Aster flaccidus bge has been used as traditional medicine in northwestern China. Two new phenylpropanoids (1–2) including one lignan: (7′R, 8S)-9′-lariciresinol-(α-methyl)-butanoate (1), 5,9-dimethoxyl-7-(α-methyl)-butanoxyl-phenyl-2E-propenol-(α-methyl)-butanoate (2) isolated from the chloroform extract of the root of Aster flaccidus bge were identified by means of extensive spectroscopic studies: 1D and 2D NMR spectra as well as HRMS analysis. They have not obvious anti-HIV-1 therapeutic activity (TI = 1.0–1.1) compared with AZT (TI = 55,556) as the result of the determination of their in vitro anti-HIV-1 activity while compound 2 displays strong antitumor activity against BEL 7402 (human liver carcinoma) with cisplatin as a positive control and the effect increases with the measuring-time going on (24 h, IC50: 106.67 ± 8.47 µM — 72 h, IC50: 50.51 ± 6.11 µM).

Two new phenylpropanoids (1–2) including one lignan were isolated from the root of Aster flaccidus bge while compound 2 displays strong antitumor activity against BEL 7402 (human liver carcinoma).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 81, Issue 2, March 2010, Pages 140–144
نویسندگان
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