کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2539268 | 1122170 | 2010 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine](/preview/png/2539268.png)
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Here we report incredibly high yields of rohitukine (7% by dry weight) from trees of Dysoxylum binetariferum.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 81, Issue 2, March 2010, Pages 145–148