کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539294 | 1122171 | 2011 | 7 صفحه PDF | دانلود رایگان |
An aqueous ethanol extract of Bergenia crassifolia rhizomes strongly inhibited human pancreatic lipase activity and increased scavenging of DPPH free radicals in vitro. Chromatographic separation of this extract led to isolation of the hydrolysable tannins (+)-catechin 3,5-di-O-gallate (1) and (+)-catechin 3-O-gallate (2). This is the first report of the isolation of compound 1 from plant material. This compound strongly inhibited human pancreatic lipase (with an IC50 value of 0.42 μg/ml) and exhibited a remarkable free radical-scavenging ability (with an SC50 value of 1.04 μg/ml). The chemical structures of 1 and 2 were elucidated using MS, NMR and chemical approaches.
A new tannin, (+)-catechin 3,5-di-O-gallate (1), and (+)-catechin 3-O-gallate (2) (A) were isolated from B. crassifolia rhizomes. The chemical structures of 1 and 2 were fully characterized (HMBC for 1 (B)).Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 82, Issue 2, March 2011, Pages 212–218