New anti-HBV caryophyllane-type sesquiterpenoids from Euphorbia humifusa Willd

Activity-guided fractionation of Euphorbia humifusa for anti-HBV activity led to the isolation of two novel sesquiterpenoids, named humifusane A (1) and humifusane B (2). Their structures were elucidated by spectral data to show that they have a caryophyllane-type precursor structure. The two new sesquiterpenoids showed anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.

Graphical AbstractTwo novel caryophyllane-type sesquiterpenoids, 1 and 2 with anti-HBV activities in vitro, were isolated from the Euphorbia humifusa.Figure optionsDownload as PowerPoint slide