Effects of a bio-assay guided fraction from Polygonum cuspidatum root on the viability, acid production and glucosyltranferase of mutans streptococci

Polygonum cuspidatum root has been traditionally used for the treatment of dental diseases in Korea. The purpose of this study was to evaluate effects of P. cuspidatum root on the development of dental caries, especially its effects against bacterial viability and caries-inducing factors of Strptococcus mutans and Strptococcus sobrinus. Among methanol extract of P. cuspidatum root and its fraction tested, ethyl acetate fraction, composed of polydatin, resveratrol, anthraglycoside B, and emodin, showed inhibitory effects on glycolytic acid production and glucosyltransferase activity of S. mutans and S. sobrinus in addition to antibacterial activities.

Ethyl acetate fraction, composed of polydatin (1), resveratrol (2), anthraglycoside B (3), and emodin (4), from Polygonum cuspidatum root showed inhibitory effects on glycolytic acid production and glucosyltransferase activity of Strptococcus mutans and Strptococcus sobrinus as well as antimicrobial activities.Figure optionsDownload as PowerPoint slide