Gastroprotective constituents of Salvia officinalis L.

The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID50 84.0 (54.8–128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H+,K+-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.

Inhibition of ethanol-induced gastric lesions and acetic acid-ulcers by hydroalcoholic extract of Salvia officinalis (HE).Figure optionsDownload as PowerPoint slide