کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2539560 1559664 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of furanoheliangolides from Tithonia diversifolia on superoxide anion generation in human neutrophils
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The effect of furanoheliangolides from Tithonia diversifolia on superoxide anion generation in human neutrophils
چکیده انگلیسی

Four known lactones were isolated from Tithonia diversifolia: furanoheliangolides 1,3-dihydroxy-3,10-epoxy-8-(-2-methylpropanoyloxy)-germacra-11(13)-ene-6,12-olide (1), 1,3-dihydroxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (2), 1,3-dimethoxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (3) and, observed in natural source for the first time, furanoheliangolide 1-hydroxy-3-methoxy-3,10-epoxy-8-(2-methylpropanoyloxy)-germacra-4,11(13)-diene-6,12-olide (4). The activity of sesquiterpene lactones on superoxide anion (O2°−) generation from PMA-activated neutrophils was evaluated. Compound 1 did not show a full dose dependent behavior. The IC100 was 8 ± 1, 12 ± 1, and 17 ± 3 μM for 2 to 4, respectively.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 78, Issues 7–8, December 2007, Pages 465–469
نویسندگان
, , , , ,