کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539685 | 1122187 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong](/preview/png/2539685.png)
A simple and sensitive HPLC–UV method was developed to determine ligustilide in rat brain samples after nasal administration. The lower limit of quantification (LLOQ) was 245 ng/ml for ligustilide. The calibration curve was linear over a concentration range of 245–4900 ng/ml. Brain samples were obtained at regular time intervals after nasal administration of ligustilide (45 mg/kg). Ligustilide could be detected in rat brain only after 5 min of nasal administration; which showed that ligustilide may have a rapid onset of action. This result illustrates that intranasal administration of ligustilide may act as a promising alternative to conventional routes of administration.
A simple and sensitive HPLC–UV method was developed to determine ligustilide in rat brain samples after nasal administration of essential oil from Rhizoma Chuanxiong.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 80, Issue 3, April 2009, Pages 168–172