کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2548926 | 1124481 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt
ترجمه فارسی عنوان
تظاهرات اتوماتیک در میوکارد ریه رگ ها با شورت آئورتوونوکوال شکمی
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS rats, but scarcely in those from sham-operated rats; the activity was induced by tertiapin and suppressed by carbachol or chelation of intracellular Ca2+. The evoked action potentials in AVS rats had less negative resting membrane potential and longer action potential duration than those in sham-operated rats. These results suggest that the automaticity of the rat pulmonary-vein myocardium is manifested under chronic volume overload.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological Sciences - Volume 128, Issue 4, August 2015, Pages 212–215
Journal: Journal of Pharmacological Sciences - Volume 128, Issue 4, August 2015, Pages 212–215
نویسندگان
Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, Takahiro Nakayama, Iyuki Namekata, Mizuki Nada, Megumi Aimoto, Akira Takahara, Hikaru Tanaka,