Neuroprotective mode of action of resveratrol in central nervous system

Resveratrol has gained importance as a naturally available medicine for the prevention of inflammatory and neurodegenerative diseases. In addition to its antioxidant properties, resveratrol also plays a significant role in neuronal differentiation through activation of SIRT1 and SIRT3. However, the receptor-mediated intracellular signal induced by resveratrol is yet to be determined. The mode of action of resveratrol presumably involves transcriptional regulation of the NF-κB family of proteins. It may also interact with the nuclear hormone receptor family, which includes estrogen receptors and vitamin D receptors in the brain. We found that resveratrol-enriched grape extract prevents paraquat-induced damage of hippocampal neurons and has the least effect on hippocampal cell damage. In this review article, we discuss the perspectives on therapeutic efficacy of resveratrol and its mode of action in neuronal cell growth and differentiation following brain inflammation and neurodegeneration.

Neuroprotective mode of action of resveratrol. Resveratrol is an antioxidant. It also regulates growth and differentiation of neuron via modulation of NF-κB, FOXO, VDR, PPAR and ER activation.Figure optionsDownload as PowerPoint slide