GABA derivatives for the treatment of epilepsy and neuropathic pain: A synthetic integration of GABA in 1, 2, 4–Triazolo–2H–one nucleus

Neuropathic pain is characterized by a neuronal hyperexcitability in damaged areas of the peripheral or central nervous system. The neuronal hyperexcitability in neuropathic pain have many common features with the cellular changes in epilepsy. This has led to the use of anticonvulsant drugs for the treatment of neuropathic pain. The present study aims at design and synthesis of two types of γ-aminobutyric acid (GABA) derivatives incorporated in the 1, 2, 4-triazol-2H-one nucleus and their evaluation for antiepileptic, peripheral analgesic, antiallodynic and antihyperalgesic potential in neuropathic pain models. Most of the synthesized triazole derivatives of GABA produced antiepileptic, antinocciceptive, antihyperalgesic, and antiallodynic actions and hence emerges as a promising lead for new drug development for the treatment of epilepsy and neuropathic pain.