کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2576415 1561353 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of hepatic injury or kidney injury on the tryptophan–niacin metabolism in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Effects of hepatic injury or kidney injury on the tryptophan–niacin metabolism in rats
چکیده انگلیسی

Hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) plays a key role in regulating NAD biosynthesis. In normal rats, ACMSD has been generally detectable only in the liver and kidneys. Therefore, there is a possibility that liver or kidney injury affects tryptophan–niacin metabolism. We previously reported the significant change of tryptophan–niacin metabolism in rats with liver cirrhosis or in rats with d-galactosamine injected liver injury. In this experiment, we investigated the change of tryptophan–niacin metabolism in rats treated with puromycin aminonucleoside (PAN)-induced nephrosis, the mechanisms responsible for their change of urinary excretion of nicotinamide and its metabolites, and the role of the kidney in tryptophan–niacin conversion. In PAN-treated rats, the sum of urinary excretion of nicotinamide and its metabolites was significantly lower compared with controls. Although kidney ACMSD activity was reduced, the conversion of tryptophan to niacin tended to be lower in the PAN-treated rats. The reduction of urinary excretion of niacin in nephrotic rats may be due to the reduction of blood tryptophan concentration. The role of the kidney ACMSD may be insignificant concerning tryptophan–niacin conversion under this experimental condition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1304, 1 November 2007, Pages 372–376
نویسندگان
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