کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2576741 | 1561358 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hashimoto's thyroiditis: Is the epithelium premalignant?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
This paper will review the pathologic definition of chronic lymphocytic thyroiditis, its relationships and epidemiology, and its association with thyroid neoplasms. The epithelium of thyroid glands affected by lymphocytic thyroiditis has been studied by various techniques. Immunohistochemical markers, oncogene changes and genetic mutations that are shared by the thyroiditic epithelium and papillary thyroid carcinoma will be reviewed. Morphologic similarities of the follicular epithelium in thyroiditis and in papillary carcinoma, similar immunohistochemical reactions with markers such as cytokeratin 19, HBME-1 and Galectin-3 and results of ret/PTC oncogene, mutational and loss of heterozygosity studies have raised questions about the nature of the thyroiditic epithelium and whether it is neoplastic or dysplastic. The results of work done in our laboratory in these areas will be compared and contrasted with work cited in the literature. This information will be assessed in terms of its clinical implications to everyday practice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1299, February 2007, Pages 281-288
Journal: International Congress Series - Volume 1299, February 2007, Pages 281-288
نویسندگان
Virginia A. LiVolsi,