Acylated ghrelin and des-acyl ghrelin exert different effects on the gastrointestinal motility in conscious rats

Acylated ghrelin and des-acyl ghrelin exert opposite effects on the gastroduodenal motility, the former induces fasted motor activity in the duodenum but the latter disrupts the fasted motor activity in the antrum. Different brain mechanisms seem to be involved in these effects, NPY might be involved in the action of acylated ghrelin, while CRF type 2 receptor might be involved in the action of des-acyl ghrelin.