کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2577464 | 1561368 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Totally synthetic peptide-based vaccines that target dendritic cells and induce potent antibody or CTL responses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
We have designed and assembled totally synthetic, epitope-based vaccines that target dendritic cells (DCs) expressing Toll-like receptor (TLR) 2 causing their activation. These self-adjuvanting vaccines comprise a helper T cell (Th) epitope, a target epitope that is recognised by CD8+ T cells or B cells and the TLR2 agonist, Pam2Cys. Lipidated vaccines, but not non-lipidated vaccines, were able to mediate protection against viral and bacterial infections and mediate prophylactic and therapeutic anti-cancer activity. High levels of anti-hormone antibodies could also be elicited which, in the case of luteinising hormone releasing hormone (LHRH), resulted in abrogation of reproductive function. These results are proof of principle for the efficacy of simple, totally synthetic, self-adjuvanting, epitope-based vaccines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1289, April 2006, Pages 311-315
Journal: International Congress Series - Volume 1289, April 2006, Pages 311-315
نویسندگان
David C. Jackson, Brendon Y. Chua, Weiguang Zeng,