کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2577467 1561368 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards the synthesis of a highly pure, multiepitopic, mucosal group A streptococcal lipopeptide vaccine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Towards the synthesis of a highly pure, multiepitopic, mucosal group A streptococcal lipopeptide vaccine
چکیده انگلیسی
Synthesis of a tri-epitopic Group A streptococcal lipopeptide vaccine was achieved using native chemical ligation. The vaccine was administered intranasally to B10.BR mice, (H-2k) with cholera toxin B-subunit (CTB) or sterile phosphate-buffered saline. Following five boosts, blood was collected for ELISA. Significant IgG antibody titres were observed to the included peptide epitopes following administration with CTB. However, no significant IgG titres were observed in the absence of CTB.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1289, April 2006, Pages 324-328
نویسندگان
, , , , , , ,