کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2578100 | 1129977 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biomarcadores, Ãndices y algoritmos para el diagnóstico de fibrosis hepática en pacientes con hepatitis crónica por virus C
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Biomarcadores, Ãndices y algoritmos para el diagnóstico de fibrosis hepática en pacientes con hepatitis crónica por virus C Biomarcadores, Ãndices y algoritmos para el diagnóstico de fibrosis hepática en pacientes con hepatitis crónica por virus C](/preview/png/2578100.png)
چکیده انگلیسی
Precise staging of liver fibrosis is essential in the management of liver disease activity in chronic hepatitis C patients. Liver biopsy has been considered the reference method for diagnosing disease, grading necroinflammatory activity, and staging fibrosis, but it has some technical limitations and risks. Taking into account these limitations, there is a need to introduce non-invasive serum markers for fibrosis that would be able to partially replace liver biopsy. Ideal serum markers should be specific for the liver and easy to perform. Serum markers of hepatic fibrosis are divided into direct and indirect. Direct markers reflect extracellular matrix turnover, whereas indirect markers reflect alterations in hepatic function. The degree of implementation of non-invasive diagnostic tests for liver fibrosis still remains limited. This review provides a current overview of biomarkers, indexes and algorithms for hepatic fibrosis diagnosis in chronic hepatitis C patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista del Laboratorio ClÃnico - Volume 8, Issue 4, OctoberâDecember 2015, Pages 179-187
Journal: Revista del Laboratorio ClÃnico - Volume 8, Issue 4, OctoberâDecember 2015, Pages 179-187
نویسندگان
MarÃa Jesús Andrés-Otero, José Manuel Lou-Bonafonte, Jesús Escanero-Marcén, Trinidad Serrano-Aulló, Juan José Puente-Lanzarote,