Diseño de un simulador de cálculo de riesgo prenatal de anomalías cromosómicas para un programa de cribado combinado en el primer trimestre de gestación

Chromosomal abnormality screening programs require the use of computer software to calculate the prenatal risk in pregnancy. This software incorporates the different formulas and statistical parameters needed to calculate the risk in terms of probability. Here, we describe the application of a simulator for calculating the risk of chromosomal abnormalities in the first trimester of pregnancy, and the evaluation of the obtained performance by using different population statistical parameters.