Efecto del cizallamiento y del difosfato de adenosina sobre la activación plaquetaria y la formación de microagregados en controles sanos. Valoración mediante citometría de flujo

Platelets subjected to shearing become refractory when they are subsequently activated by action of a physiological agonist such as ADP. However the platelets that are not sheared respond appropriately to this agonist. This refractory response in vitro may represent a cellular defence mechanism to prevent a greater degree of in vivo activation-aggregation when platelets are faced with an agonist in areas where the shear rate increases in the blood flow.