کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2578900 | 1561485 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effets indésirables de la sulfasalazine : discussion de leur mécanisme et du rôle de la composante sulfamidée
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کلمات کلیدی
TCDEMPAAN - ONEffet indésirable - اثر متضادadverse effect - اثر نامطلوبDrug rash with eosinophilia and systemic symptoms - بثورات دارویی با ائوزینوفیلیا و علائم سیستمیکmaladies inflammatoires chroniques de l’intestin - بیماری روده التهابیDRESS syndrome - سندرم DRESSSulphasalazine - سولفازالازینsulfasalazine - سولفاسالازینEffets indésirables - عوارض جانبیMécanisme - مکانیزمMechanism - مکانیسم یا سازوکارMICI - کوچک
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
فارماکولوژی، سم شناسی و اقلام دارویی (عمومی)
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چکیده انگلیسی
Sulfasalazine is widely used in the treatment of chronic inflammatory bowel disease (IBD) and certain rheumatic diseases. However, its use is associated with a high rate of adverse effects (AEs) which can be cutaneous, hematological, renal, hepatic, gastrointestinal or neurological. The aim of our study was to collect all cases of AEs suspected to be associated with the use of sulfasalazine in patients hospitalized in the department of Gastroenterology from the Hospital Hedi Chaker of Sfax (Tunisia) for a period of 5 years and to search the incriminated fraction (sulfonamide or salicylate). Our study population included 69 patients who received sulfasalazine for the treatment of IBD. We collected, in 23 patients (33%), 25 AEs suspected to be related to sulfasalazine. Cutaneous and hematological reactions are the most common. The subsequent administration of mesalazine was performed in 15 patients. It was well tolerated in 14 patients. So we were suspecting probably the responsibility of sulfonamide fraction in these cases. The mechanism of sulfasalazine induced AEs may be toxic or immunoallergic with the possibility of a cross-reaction with the other antimicroacterial sulfonamides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thérapie - Volume 68, Issue 6, NovemberâDecember 2013, Pages 369-373
Journal: Thérapie - Volume 68, Issue 6, NovemberâDecember 2013, Pages 369-373
نویسندگان
Rim Atheymen, Hanen Affes, Kamilia Ksouda, Leila Mnif, Zouheir Sahnoun, Nabil Tahri, Khaled Mounir Zeghal, Serria Hammami,