کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2579113 | 1561487 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toxoplasmose congénitale : comparaison randomisée de stratégies de prévention des rétinochoroïdites
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
فارماکولوژی، سم شناسی و اقلام دارویی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Toxoplasmose congénitale : comparaison randomisée de stratégies de prévention des rétinochoroïdites Toxoplasmose congénitale : comparaison randomisée de stratégies de prévention des rétinochoroïdites](/preview/png/2579113.png)
چکیده انگلیسی
In France, children with confirmed congenital toxoplasmosis receive a treatment for a period of 12 to 24 months. Such prolonged treatment may generate potentially severe risks, in particular hematologic and cutaneous. Our objective is to compare the effectiveness of two therapeutic strategies on the prevention of retinochoroiditis by a randomized, non-inferiority, openlabel, parallel study including 486 children, 3 to 6 months of age with a non-severe form of congenital toxoplasmosis. Following randomization, pyrimethamine-sulphonamide treatment is initiated for a period of three months, followed by a treatment with Fansidar® for 9 months, or therapeutic abstention. Follow-up visits during a two-year period will include an examination of the eye, a blood test, and questionnaires to evaluate the children's quality of life and their parents' anxiety. Confirming the non-inferiority of the effectiveness of a short-term treatment will improve the quality of life of parents and children.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thérapie - Volume 66, Issue 6, NovemberâDecember 2011, Pages 473-480
Journal: Thérapie - Volume 66, Issue 6, NovemberâDecember 2011, Pages 473-480
نویسندگان
Martine Wallon, François Kieffer, Christine Binquet, Philippe Thulliez, Patricia Garcia-Méric, Pascal Dureau, Jacqueline Franck, François Peyron, Alain Bonnin, Isabelle Villena, Claire Bonithon-Kopp, Jean-Bernard Gouyon, Sandrine Masson,