کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2579279 1130039 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Traitement symptomatique de la maladie d'Alzheimer et perspectives thérapeutiques
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی فارماکولوژی، سم شناسی و اقلام دارویی (عمومی)
پیش نمایش صفحه اول مقاله
Traitement symptomatique de la maladie d'Alzheimer et perspectives thérapeutiques
چکیده انگلیسی
The progressive neuronal loss in Alzheimer's disease leads to neurochemical abnormalities which provide the basis for symptomatic treatments. Four cholinesterase inhibitors were released in this indication. Meta-analyses have confirmed a beneficial effect on cognitive functioning and activities of daily living. The NMDA receptor antagonist, memantine, was also approved for the treatment of moderate to severe and may be associated. Progress in the patho-physiology of the disease offers some hope of new treatments acting on the cerebral lesions. The amyloid hypothesis allowed the emergence of active or passive immunotherapies, and of secretase inhibitors or modulators. Recent studies have targeted the P tau protein. The brain plasticity and the uses of stem cells offer more distant hope.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thérapie - Volume 65, Issue 5, September–October 2010, Pages 429-437
نویسندگان
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