کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2585208 | 1561790 | 2013 | 11 صفحه PDF | دانلود رایگان |
Unborn children are exposed to environmental pollutants via the placenta, and there is a causal relationship between maternal intake of pollutants and fetal exposure. Placental examination is an effective way for acquiring data for estimating fetal exposure. We analyzed the concentrations of 104 congeners of persistent organic pollutants, seven organotin compounds, five heavy metals, and methylmercury in 130 randomly selected placentas. Additionally, we examined similarities between pollutant concentrations by analyzing correlations between their placental concentrations. Our results yield new information for conducting contaminant risk assessments for the prenatal period. Out of the 117 individual persistent organic pollutants or metals assayed, 46 could be detected in more than half of the placentas. Moreover, dichlorodiphenyldichloroethylene (p,p′-DDE) was found in all placentas. The data indicates that fetal exposure to dioxins and furans (PCDD/Fs), polychlorinated biphenyls (PCBs), p,p′-DDE, and methylmercury depends on the mother’s parity, and age. We also conclude that sources of the above four pollutants are similar but differ from the sources of polybrominated diphenyl ethers.
► We assayed an extensive number of environmental pollutants in human placenta.
► We examined correlations between the placental pollutant concentrations.
► We found differences in how compound groups transfer or remain in the placenta.
► Placental exposure of organic pollutant clearly depends on parity and maternal age.
► Exposure sources of brominated flame retardants differ from the other pollutants.
Journal: Food and Chemical Toxicology - Volume 54, April 2013, Pages 59–69