کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2585246 1561792 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils
چکیده انگلیسی

Dietary quercetin is highly abundant in edible plants, which possesses a wide range of pharmacological properties. This study was to investigate hepatoprotective effects of quercetin in the nonalcoholic steatohepatitis (NASH) gerbils induced by a high-fat diet (HFD), and to evaluate its regulatory mechanism on hepatic inflammatory response. The gerbils were fed with HFD for 28 days to induce NASH. From 15th day to 28th day, the treated drugs were given daily to each animal, respectively. The lipid profiles and biochemical markers were determined at the end of the experiment. The expressions of Sirt1, NF-κB p65 and iNOS were detected by immunohistochemistry and Western blot analysis. The results showed that oral administration of quercetin at doses of 30–60 mg/kg to hyperlipidemia rats for 14 days were highly effective in decreasing the levels of serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). It could decrease lipid accumulation in the hepatocytes, and reduce serum levels of pro-inflammatory cytokines TNF-α and IL-6 via regulating the expressions of Sirt1, NF-κB p65 and iNOS. Thus, dietary quercetin had significant therapeutic benefits and could be explored as a potential promising candidate for the prevention of NASH.


► Quercetin ameliorates biochemical markers of liver inflammation in NASH gerbils.
► Quercetin ameliorates histological features of liver steatosis in NASH gerbils.
► Quercetin regulates protein levels of Sirt1, NF-κB p65 and iNOS in the liver.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 52, February 2013, Pages 53–60
نویسندگان
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