کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2585294 1130857 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fragrance material review on p-α,α-trimethylbenzyl alcohol
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Fragrance material review on p-α,α-trimethylbenzyl alcohol
چکیده انگلیسی

A toxicologic and dermatologic review of p-α,α-trimethylbenzyl alcohol when used as a fragrance ingredient is presented. p-α,α-Trimethylbenzyl alcohol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a tertiary alcohol. The AAAs are a structurally diverse class of fragrance ingredients that includes primary, secondary, and tertiary alkyl alcohols covalently bonded to an aryl (Ar) group, which may be either a substituted or unsubstituted benzene ring. The common structural element for the AAA fragrance ingredients is an alcohol group –C–(R1)(R2)OH and generically the AAA fragrances can be represented as an Ar-C-(R1)(R2)OH or Ar–Alkyl–C-(R1)(R2)OH group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for p-α,α-trimethylbenzyl alcohol were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitisation, toxicokinetics, and genotoxicity data. A safety assessment of the entire Aryl Alkyl Alcohols will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Aryl Alkyl Alcohols in fragrances.Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2012. A Toxicologic and dermatologic assessment of aryl alkyl alcohols when used as fragrance ingredients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 50, Supplement 2, September 2012, Pages S113–S116
نویسندگان
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