Fragrance material review on 2-hexylidene cyclopentanone

A toxicologic and dermatologic review of 2-hexylidene cyclopentanone when used as a fragrance ingredient is presented. 2-Hexylidene cyclopentanone is a member of the fragrance structural group ketones alkyl cyclic. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-hexylidene cyclopentanone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, and genotoxicity data. A safety assessment of the entire ketones alkyl cyclic will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all ketones alkyl cyclic in fragrances.Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2012. A toxicological and dermatological assessment of aryl alkyl alcohol simple acid ester derivatives when used as fragrance ingredients. Food and Chemical Toxicology. http://dx.doi.org/10.1016/j.fct.2012.02.091.