کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2585607 1130876 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid
چکیده انگلیسی

We evaluated renal melamine–cyanurate crystal spherulite formation after single and repeated ingestion of both melamine (MEL) and cyanuric acid (CYA) in catfish and trout. MEL and CYA were co-administered orally over a range of doses, 0.1–20 mg/kg body weight (bw) of each compound, either once or repeatedly for 4, 14 or 28 days (d). In catfish, the No Observable Adverse Effects Levels (NOAELs) for crystal formation for single, 4 d or 14 d dosing were 10, 2.5 and 0.5 mg/kg bw, respectively. In trout, the respective NOAELs were 2.5, 2.5 and 0.5 mg/kg bw. No renal crystals formed in catfish fed 0.1 mg/kg bw of each compound for 28 d. Sequential administration of 20 mg/kg bw of MEL followed by 20 mg/kg bw of CYA or vise-versa, with waiting periods of 1, 3, 7, 14 or 21 d between compound dosing also induced renal crystal formation in fish. These studies show that both catfish and trout are sensitive, non-mammalian models, for renal crystal formation following MEL and CYA ingestion. Since fish generally excrete chemicals more slowly than mammals, they may provide a “worst case scenario” model for higher risk populations, such as infants or persons with compromised renal function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 10, October 2010, Pages 2898–2906
نویسندگان
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