کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2585634 | 1130877 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: Example: (CAS No. 96-23-1) 1,3-Dichloro-2-propanol (DCP)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
1,3-Dichloro-2-propanol (DCP) is formed in foods under a variety of conditions. It was positive in a variety of in vitro genotoxicity tests, but was negative in two in vivo studies. DCP produced neoplasms at several sites in rats. Kidney tumours in male rats were selected as the critical tumour type. Dose–response modelling of the data for DCP gave a BMDL10 for combined kidney carcinomas and adenomas in male rats of 9.62 mg/kg-body weight (bw)/day. The exposure of humans was estimated at an average of 0.00009 mg/kg-bw/day and a high exposure of 0.000136 mg/kg-bw/day. The MOEs for these exposures were 100,000 and 70,000, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Supplement 1, January 2010, Pages S57–S62
Journal: Food and Chemical Toxicology - Volume 48, Supplement 1, January 2010, Pages S57–S62
نویسندگان
Gary Williams, Jean-Charles Leblanc, R. Woodrow Setzer,