کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2585637 1130877 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: Leucomalachite green
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Example: Leucomalachite green
چکیده انگلیسی

Leucomalachite green (LMG) is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for hepatocellular adenomas and carcinomas in female mice gave a BMDL10 of 20 mg/kg-bw/day. Limited data are available on the concentrations present in fish for human consumption. Human exposure estimates assumed that all consumed fish is contaminated with LMG. The calculated MoEs were 4,000,000 and 400,000 respectively for average and high exposure estimates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Supplement 1, January 2010, Pages S75–S80
نویسندگان
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