کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2585920 | 1130884 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage
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کلمات کلیدی
LMPAPBSIshige okamuraeNMPADCFH-DA2′,7′-dichlorodihydrofluorescein diacetate - 2 '، 7'-dichlorodihydrofluorescein diacetateDMSO - DMSOMTT - MTTROS - ROSDNA damage - آسیبDNAUltraviolet - اشعه فرابنفشoptical densities - تراکم نوریdiphlorethohydroxycarmalol - دیفلورت هیدروکسیرارمالولDimethylsulfoxide - دیمتیل سولفواکسیدphosphate buffer saline - فسفات بافر شورPhlorotannin - فلوترانینMelanogenesis - ملانوژنزnormal melting point agarose - نقطه ذوب طبیعی آگارزlow melting point agarose - نقطه ذوب پایین آگارزPropidium iodide - پروتئین یدیدReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In this study, potential inhibitory effect of 21 species of marine algae on melanogenesis was assessed via tyrosinase inhibitory effect. The Ishige okamurae extract tested herein evidenced profound tyrosinase inhibitory effect, compared to that exhibited by other marine algae extracts. Thus, I. okamurae was selected for use in further experiments, and was partitioned with different organic solvents. Profound tyrosinase inhibitory effect was detected in the ethyl acetate fraction, and the active compound was identified as the carmalol derivative, diphlorethohydroxycarmalol (DPHC), which evidenced higher levels of activity than that of commercial whitening agent. Intracellular reactive oxygen species (ROS) induced by ultraviolet (UV)-B radiation was reduced by the addition of DPHC and cell viability was dose-dependently increased. Moreover, DPHC demonstrated strong protective properties against UV-B radiation via damaged DNA tail length and morphological changes in fibroblast. Hence, these results indicate that DPHC isolated from I. okamurae has potential whitening effects and prominent protective effects on UV-B radiation-induced cell damages which might be used in pharmaceutical and cosmeceutical industries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 5, May 2010, Pages 1355-1361
Journal: Food and Chemical Toxicology - Volume 48, Issue 5, May 2010, Pages 1355-1361
نویسندگان
Soo-Jin Heo, Seok-Chun Ko, Sung-Myung Kang, Seon-Heui Cha, Seung-Hong Lee, Do-Hyung Kang, Won-Kyo Jung, Abu Affan, Chulhong Oh, You-Jin Jeon,