کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2586261 1130896 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety evaluation of polydextrose in infant formula using a suckling piglet model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Safety evaluation of polydextrose in infant formula using a suckling piglet model
چکیده انگلیسی

Oligosaccharides, the third largest component in human milk, are virtually absent from cow’s milk and most infant formula. Prebiotic carbohydrates like polydextrose (PDX) have been proposed as surrogates for human milk oligosaccharides. Safety assessments of novel infant formula ingredients include dose-response experiments in appropriate neonatal animal models such as the suckling pig. To further substantiate the safety of the ingredient, one-day old pigs were fed a cow’s milk-based formula supplemented with PDX (1.7, 4.3, 8.5 or 17 g/L) for 18 days (n = 13/dose) and compared to appropriate control (unsupplemented formula; n = 13) and reference groups (day 0 pigs, and sow-reared pigs; n = 13). Growth rate, formula intake, stool consistency, behavior score, blood chemistry and hematology, relative organ weights (% of body weight), tissue morphology (i.e. liver, kidney and pancreas) and pancreas biochemistry did not differ among formula-fed pigs (P > 0.1). Polydextrose mimicked other prebiotic carbohydrates and had no adverse effect at the highest tested level 17.0 g PDX/L, equivalent to a dose of 8.35 g/kg of body weight per day.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 47, Issue 7, July 2009, Pages 1530–1537
نویسندگان
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