کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2586664 | 1130907 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Jamaica quassia extract (JQE), a natural bittering agent, was investigated for hepatocarcinogenesis-promoting potential using a medium-term liver bioassay system. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (200Â mg/kg body weight) and then starting 2 weeks later, received JQE in the diet at concentrations of 500, 5000 or 30,000Â ppm for 6 weeks. Animals for tumor promotion (+) and (â) controls were fed 500Â ppm sodium phenobarbital (PB) and basal diet, respectively during the promotion phase in this model. All animals were subjected to two-thirds partial hepatectomy at week 3 and killed at week 8. As with the PB-promoted case, both numbers and areas of glutathione S-transferase placental form-positive liver cell foci were significantly increased by JQE at 30,000Â ppm, with non-significant increases evident at 5000Â ppm. The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 45, Issue 7, July 2007, Pages 1160-1164
Journal: Food and Chemical Toxicology - Volume 45, Issue 7, July 2007, Pages 1160-1164
نویسندگان
Gye-Hyeong Woo, Makoto Shibutani, Kaoru Inoue, Hitoshi Fujimoto, Miwa Takahashi, Kyoung-Youl Lee, Masao Hirose,