کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2586720 1130909 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dietary diphenyl diselenide reduces the STZ-induced toxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Dietary diphenyl diselenide reduces the STZ-induced toxicity
چکیده انگلیسی

Oxidative stress is implicated in the pathogenesis of diabetes mellitus. Selenium supplementation has some benefits in experimental models of diabetes mellitus. This study evaluated whether dietary diphenyl diselenide, a simple synthetic organoselenium compound with antioxidant properties, reduces the streptozotocin (STZ)-induced toxicity. STZ-induced diabetic rats were fed with either standard and diphenyl diselenide (10 ppm) supplemented diets. In experimental trials, dietary diphenyl diselenide significantly decreased mortality rate (p < 0.05) induced by STZ treatment. No correlation between this effect and glycemic levels were found. Diphenyl diselenide intake also promoted an increase in vitamin C, –SH levels (liver, kidney and blood) and in catalase (liver and kidney) activity, which were decreased in STZ-treated rats. In enzyme assays, diphenyl diselenide supplementation caused a significant improvement in platelets NTPDase and 5′-nucleotidase activities in STZ-induced diabetic rats when compared to the control and diabetic groups (p < 0.05). Nevertheless, this supplementation did not modify the inhibition induced by STZ in δ-ALA-D activity. Our findings suggest that diphenyl diselenide compound showed beneficial effects against the development of diabetes by exhibiting antioxidant properties.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 1, January 2008, Pages 186–194
نویسندگان
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