کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2587051 | 1130916 | 2006 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000Â ppm) and methylethylketone (MEK; 0, 1000, or 3000Â ppm), alone and in combination, by inhalation, for 6Â h/day, during days 6-20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000Â ppm EB and 3000Â ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000Â ppm EB or 3000Â ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 44, Issue 8, August 2006, Pages 1287-1298
Journal: Food and Chemical Toxicology - Volume 44, Issue 8, August 2006, Pages 1287-1298
نویسندگان
A.M. Saillenfait, F. Gallissot, J.P. Sabaté, N. Bourges-Abella, R. Cadot, G. Morel, A.M. Lambert,