کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587204 1130919 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Skin decontamination: Importance of the wash-in effect
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Skin decontamination: Importance of the wash-in effect
چکیده انگلیسی

That skin washing/decontamination may increase percutaneous absorption is commonly referred to as the ‘wash-in’ (W-I) effect. This article traces the development of the W-I effect both in vivo and more recently in vitro. The mechanism(s) responsible for this effect are examined particularly in relation to the laboratory method used in vitro. The importance of the W-I effect is presented and it is recommended that caution be practiced when skin is washed as the W-I effect may increase both local cutaneous and general systemic toxicity. Experimental data on a wide variety of chemicals are urgently needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 44, Issue 11, November 2006, Pages 1783–1788
نویسندگان
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