کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587321 1130925 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rebaudioside A: Two-generation reproductive toxicity study in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Rebaudioside A: Two-generation reproductive toxicity study in rats
چکیده انگلیسی

Rebaudioside A was administered via the diet to male and female Han Wistar rats at 0, 7500, 12,500, and 25,000 ppm for two generations. Rebaudioside A treatment was not associated with any signs of clinical toxicity or adverse effects on body weight, body weight gain, or food consumption. No treatment-related effects of rebaudioside A were observed in either the F0 or F1 generations on reproductive performance parameters including mating performance, fertility, gestation lengths, oestrous cycles, or sperm motility, concentration, or morphology. The survival and general condition of the F1 and F2 offspring, their pre-weaning reflex development, overall body weight gains, and the timing of sexual maturation, were not adversely affected by rebaudioside A treatment.The NOAEL for reproductive effects was 25,000 ppm and the NOAEL for the survival, development, and general condition of the offspring also was considered to be 25,000 ppm or 2048–2273 mg/kg body weight/day.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 7, Supplement, July 2008, Pages S21–S30
نویسندگان
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