کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587511 1130931 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats
چکیده انگلیسی

Dietary supplements containing “starch blockers” are believed to reduce carbohydrate-derived calories by interfering with α-amylase, the digestive enzyme responsible for conversion of complex carbohydrates to simple, absorbable sugars. The present paper reports the findings of a 28-day oral toxicity study in rats of Phase 2®, a standardized extract derived from the common white kidney bean (Phaseolus vulgaris), which has been shown to have α-amylase-inhibiting activity. In order to establish safety, eighty male and female Sprague-Dawley rats (10 animals/sex/group) received Phase 2®via oral gavage at doses of 0, 625, 1250, and 2500 mg/kg (7 days/wk) for a period of 31 (males) or 32 (females) days. There were no mortalities, clinical signs, body weight or nutritional effects, gross alterations, clinical or histopathological alterations that were considered attributable to test substance administration. Under conditions of this study and based on toxicological endpoints evaluated, the no-observed-adverse-effect level (NOAEL) of Phase 2® was judged to be 2500 mg/kg/day in each sex for administration by oral gavage of a standardized white kidney bean extract, Phase 2® for 28 days.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 45, Issue 1, January 2007, Pages 32–40
نویسندگان
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