کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2587682 1130935 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
چکیده انگلیسی

We recently reported that chlorophyll (Chl) strongly inhibits aflatoxin B1 preneoplasia biomarkers in rats when administered by co-gavage (Simonich et al., 2007. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis 28, 1294–1302.). The present study extends this by examining the effects of dietary Chl on tumor development, using rainbow trout to explore ubiquity of mechanism. Duplicate groups of 140 trout were fed diet containing 224 ppm dibenzo[a,l]pyrene (DBP) alone, or with 1000–6000 ppm Chl, for 4 weeks. DBP induced high tumor incidences in liver (51%) and stomach (56%), whereas Chl co-fed at 2000, 4000 or 6000 ppm reduced incidences in stomach (to 29%, 23% and 19%, resp., P < 0.005) and liver (to 21%, 28% and 26%, resp., P < 0.0005). Chlorophyllin (CHL) at 2000 ppm gave similar protection. Chl complexed with DBP in vitro (2Chl:DBP, Kd1 = 4.44 ± 0.46 μM, Kd2 = 3.30 ± 0.18 μM), as did CHL (Kd1 = 1.38 ± 0.32 μM, Kd2 = 1.17 ± 0.05 μM), possibly explaining their ability to inhibit DBP uptake into the liver by 61–63% (P < 0.001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 46, Issue 3, March 2008, Pages 1014–1024
نویسندگان
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