کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2588175 | 1130955 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute toxicity of sodium arsenite in a complex food matrix
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Acute toxicity of sodium arsenite in a complex food matrix Acute toxicity of sodium arsenite in a complex food matrix](/preview/png/2588175.png)
چکیده انگلیسی
Acute toxicity of a single oral dose of sodium arsenite (As), administered in half and half cream (HH), was assessed in male and non-pregnant female rats (0.41, 4.1, 41.0 and 410.0Â mg/kg body weight) and pregnant rats (0.41, 4.1 and 41.0Â mg/kg body weight). Control rats received deionized water alone, HH alone or 41.0Â mg/kg As in deionized water (41Â mg/kg As-water). Male and non-pregnant rats were monitored for 14 consecutive days post-dosing. Pregnant rats, dosed on gestation day 10 (GD-10), were monitored until fetuses were collected on GD 20. High mortality (100%) was observed in male and non-pregnant female rats exposed to 410.0Â mg/kg As-HH. Low mortality (25%) was observed in non-pregnant female rats exposed to 41Â mg/kg As-water. No mortality was observed in other control or treated groups. Reduced female fetal numbers were observed in the 41Â mg/kg As-water group but not in the other control groups. Developmental effects were not observed in the controls or the As-HH treatment groups. In conclusion, As toxicity was not reduced when a high dose (410Â mg/kg) was administered in HH however, at lower doses (41Â mg/kg), HH reduced acute As oral toxicity in the female and developing fetus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 45, Issue 9, September 2007, Pages 1606-1613
Journal: Food and Chemical Toxicology - Volume 45, Issue 9, September 2007, Pages 1606-1613
نویسندگان
R.L. Sprando, T.F.X. Collins, T. Black, N. Olejnik, M. Ramos-Valle, D. Ruggles,